Commissariat a L'energie Atomique

Other

Centre National De La Recherche Scientifique

Université´ D'aix-Marseille

Ecole Centrale De Marseille

Anabela Da Silva

Jean-Marc Dinten

Philippe Rizo

Lionel Herve

Jérôme Bibette

Mathieu Goutayer

Isabelle Texier-Nogues

Anne Koenig

Laurent Guyon

Michel Berger

Aurélie Laidevant

Serge Mensah

Jacques Fattaccioli

A method for locating at least one target, in an electromagnetically absorbent environment, includes: emitting at least one electromagnetic excitation signal from a source; receiving, by an acoustic sensor, an acoustic signal from emission of the excitation signal; detecting, in the received acoustic signal, a first time of receipt of a first response to the excitation signal from an acoustic disturbance caused by electromagnetic heterogeneity of the target in the environment; estimating a first distance between the target and the acoustic sensor using the first time of receipt; detecting, in the same received acoustic signal, a second time of receipt of a second response to the excitation signal from an acoustic disturbance caused by acoustic heterogeneity of the target in the environment; estimating a second distance between the source and target using the second time of receipt; obtaining a location of the target from the first and second estimated distances.

Method and device for locating at least one target in an electromagnetically absorbent environment

The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.

Fluorescent emulsions for optical imaging

The invention relates to a method of localising a fluorophore () in a scattering medium (), by means of a radiation source () suited to emitting an excitation radiation of this fluorophore and detection means () suited to measuring a fluorescence signal (&#x3a6;) emitted by this fluorophore () comprising:

Method and device for localising fluorophores or absorbers in a surrounding medium

An optical device intended for the analysis of a scattering medium, including at least one light source distant from the scattering medium and capable of providing an incident light beam intended to illuminate the scattering medium; at least one sensor capable of detecting a radiation emitted by the scattering medium; a support of the scattering medium at least partially non-absorbing for the incident light beam and the scattered radiation. All or part of the support is formed of a scattering material having a decreased scattering coefficient greater than 0.1 cmand smaller than 700 cm.

Optical device for analyzing a scattering medium held by a support

A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime &#x3c4; in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of &#x3c4;, of the position or the distribution of fluorophore in said medium.

Method and device for 3D reconstruction of the distribution of fluorescent elements

The method enables a non-homogeneous diffusing object to be examined by illuminating the object with a continuous light by means of a light source. It previously comprises reconstruction of the three-dimensional spatial mapping of an attenuation variable representative of the diffusion and absorption non-homogeneities of the object, by resolving a diffusion equation&#x2207;()&#x2212;()()=&#x3b4;().In the diffusion equation, Ais a constant, {right arrow over (r)} the spatial coordinate of any point of the mesh of a volume at least partially containing the object, and {right arrow over (r)}the spatial coordinate of the light source. The transfer functions of an equation used for reconstructing the distribution of fluorophores integrate the attenuation variable reconstituted in this way.

Method for reconstructing the distribution of fluorophores in a non-homogeneous medium by optical tomography in continuous mode

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Marseilles, France

Anabela Da Silva