Baxter International Inc.

Ana Srnak

Ton That Hai

Deanna J Nelson

A non-immunogenic mixture of hemoglobin based modified monomers and oligomers produced by the polymerization of a hemoglobin based solution in the presence of a three membered heterocyclic ring, i.e. polyether oxirane. The modified hemoglobin composition has a P.sub.50 of at least equivalent to the P.sub.50 of human red blood cell hemoglobin.

Oxirane-modified hemoglobin based composition

A process for the production of crosslinked hemoglobin comprises crosslinking hemoglobin in the presence of sodium tripolyphosphate.

Process for the production of crosslinked hemoglobin in the presence of

Bis(salicyl) diesters useful as cross-linking agents for hemoglobin are prepared in high yield and purity by reacting salicylic acid or a derivative thereof with a lower aliphatic dicarboxylic acid halide in a lower aliphatic ketone or nitrile solvent in the presence of a pyridine derivative. The desired diester is recovered from the resulting insoluble pyridine derivative salt.

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Skokie, IL, United States of America

Ana Srnak