Ajinomoto Co., Ltd.

Ana San Gabriel

Hisayuki Uneyama

Kunio Torii

Takami Maekawa

An isolated DNA molecule which encodes a novel glutamate receptor and a transformed cell expressing the receptor are provided.

Glutamate receptors and utilization thereof

The inventive subject matter relates to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method for identifying an agonist for glutamic acid, an antibody to the receptor, and processes for making glutamate receptor modulators and pharmaceutical compositions comprising said modulator.

Glutamate receptor and utilization thereof

An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction: (A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or (B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein.

Growing community of inventors

Kawasaki, Japan

Ana San Gabriel