Abbott Laboratories Corporation

Abbott Gmbh & Co Kg

Ana Pereda-Lopez

Leonard Katz

Diane L Stassi

Richard G Summers, Jr

Stephan J Kakavas

Xiaoan Ruan

Boris Labkovsky

Heinz Hillen

Ulrich Ebert

Stefan Barghorn

Edward T Olejniczak

John E Harlan

Thomas F Holzman

Rohinton P Edalji

Liping Yu

The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.

Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with &mdash;H, -Et, and/or &mdash;OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

Polyketide derivatives and recombinant methods for making same

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxycyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, --Et, and/or --OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

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Mundelein, IL, United States of America

Ana Pereda-Lopez