Fundacion Para La Investigacion Medica Aplicada

Fundación La Investigación Médica Aplicada

Ana María García Osta

Julen Oyarzabal Santamarina

Maria Obdulia Rabal Gracia

María Del Mar Cuadrado Tejedor

Juan Antonio Sánchez Arias

Ana Ugarte Baztán

Rafael Franco Fernández

Novel compounds for use in cognition improvement It relates to certain compounds having a polycyclic structure and a &#x2014;(C&#x2550;O)NRRmoiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurode-generative diseases.

Compounds for use in cognition improvement

It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to a process for their preparation, as well as to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases. wherein Bis a radical selected from the group consisting of formula (A&#x2033;), formula (B&#x2033;), formula (C&#x2033;), and formula (D&#x2033;): 

Compounds as dual inhibitors of phosphodiesterases and histone deacetylases

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Pamplona, Spain

Ana María García Osta