Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Centro Nacional De Investigaciones Oncologicas (cnio)

Ana Maria Garcia Collazo

Paolo Pevarello

Sonia Martínez González

Jose Ignacio Martín Hernando

Joaquín Pastor Fernández

Antonio Rodríguez Hergueta

Carmen Blanco Aparicio

Ana Isabel Hernández Higueras

Francisco Javier Ramos Lima

Carl-Gustave Pierre Saluste

Esther Gonzalez Cantalapiedra

Antonio Salgado Serrano

Beatriz Noya Marino

Ana Belen Garcia Garcia

Esther González Cantalapiedra

José Ignacio MARTÍN Hernando

Beatriz Noya Mariño

There is provided compounds of formula (I), wherein R, R, Rand Rhave meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I). 

Tricyclic compounds for use as kinase inhibitors

There is provided compounds of formula (I), wherein Z, M, R, X, R, Rand B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, and particularly in the treatment of cancer. 

Imidazolothiadiazoles for use as protein kinase inhibitors

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Ana Maria Garcia Collazo