University System of Maryland

Ana Luisa Palhares De Miranda

Edson X Albuquerque

Roberto Takashi Sudo

Newton Goncalves De Castro

Paulo De Assis Melo

Carlos Alberto Manssour Fraga

Claudia Lucia Martins Da Silva

Wagner Monteiro Cintra

Patricia Dias Fernandes

Eliezer J De Barreiro

Francois Germain Noel

Yasco Aracava

Gisele Zapata Sudo

The invention discloses a compound having the formula (I) wherein Ris selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; Ris selected from the group consisting of H, alkene, un-substituted phenol, and substituted phenyl; and pharmaceutically acceptable salts thereof, having digitalis-like properties. The invention further discloses a novel method to synthesize 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294). LASSBio-294 produces positive inotropic effect on cardiac and skeletal muscle. The invention is useful for the treatment of congestive heart failure and muscle fatigue. It lacks toxic effects seen in digitalis glycosides.

Thienylhydrazon with digitalis-like properties (positive inotropic effects)

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Petropolis, Brazil

Ana Luisa Palhares De Miranda