Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncologicas Carlos III (f.s.p. Cnio)

Centro Nacional De Investigaciones Oncologicas (cnio)

Ana Isabel Hernández Higueras

Sonia Martínez González

Joaquín Pastor Fernández

Jose Ignacio Martín Hernando

Antonio Rodríguez Hergueta

Carmen Blanco Aparicio

Rosario Concepción Riesco Fagundo

Francisco Javier Ramos Lima

Ana Maria Garcia Collazo

Carmen Varela Busto

Cristina Ana Gómez De La Oliva

Virginia Rivero Buceta

Carl-Gustave Pierre Saluste

Esther Gonzalez Cantalapiedra

Carmen Blanco-Aparicio

Antonio Salgado Serrano

Beatriz Noya Marino

Esther González Cantalapiedra

José Ignacio MARTÍN Hernando

Rosa María Alvarez Escobar

Esther GONZÁLES Cantalapiedra

Sonsoles RODRÍGUEZ Aristegui

Beatriz Noya Mariño

There is provided compounds of formula I, wherein R, R, RR, R, R, Rand Rhave meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.

Condensed tricyclic compounds as protein kinase inhibitors

There is provided compounds of formula (I), wherein R, R, Rand Rhave meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I). 

Tricyclic compounds for use as kinase inhibitors

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Madrid, Spain

Ana Isabel Hernández Higueras