Beth Israel Deaconess Medical Center, Inc.

Janssen Pharmaceuticals, Inc.

An Vandebosch

Dan H Barouch

Jerald C Sadoff

Johannes Petrus Maria Langedijk

Lucy Rutten

Frank Wegmann

David Adrianus Theodorus Maria Zuijdgeest

Rinke Bos

Mathieu Claude Michel Le Gars

Mark Johannes Gerardus Bakkers

The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines.

Compositions and methods for preventing and treating coronavirus infection&#x2014;SARS-CoV-2 vaccines

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Herentals, Belgium

An Vandebosch