Amgen Inc.

University of Pennsylvania

Amgen Sf, LLC

Tularik Limited

An-Rong Li

Julio Cesar Medina

Jiwen Liu

Michael G Johnson

Xiaohui Du

Zice Fu

Andrew P Marcus

Liusheng Zhu

William R Dolbier, Jr

Yingcai Wang

Cameron J Koch

Alexander V Kachur

Xiaoqi Chen

Wang Shen

Jeffrey Thomas Mihalic

Jason A Duquette

Jeffrey Deignan

Darin J Gustin

Alan X Huang

Philippe Bergeron

Jonathan B Houze

Ming Yu

Paul John Dransfield

Vatee Pattaropong

Sean P Brown

Marc Vimolratana

Yongli Su

SuJen Lai

Brian R James

Kirsten A Skov

Sydney M Evans

Chyng-Yann Shiue

Ian R Baird

Matthew Irvine Brown

Jian Luo

Zhihua Ma

Alan Martin Allgeier

Joseph F Payack

Sarah Lively

Gayathri Swaminath

Zhongyu Wang

Jie Zhang

Todd J Kohn

YuMei Xiong

XianYun Jiao

Xian Yun Jiao

Thomas Storz

Jerry A Murry

Margrit Schwarz

Mark Grillo

Yong-Jae Kim

Xuemei Wang

Jeffrey D Reagan

Jacqueline E Milne

Qiong Cao

Matthew Brown

Li Yang

Janan Jona

Daniel Lin

Sarah E Lively

Jacqueline Milne

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I&#x2032;B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Spirocyclic GPR40 modulators

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Phenyl acetic acid derivatives

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Substituted biphenyl GPR40 modulators

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Compounds and methods useful for treating asthma and allergic inflammation

Compounds are provided having the formula: wherein variables R, R, R, R, R, A, A, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

NovelF-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Preparation of compounds useful for the detection of hypoxia

Compounds are provided having the formula: wherein variables A, A, A, A, R, R, R, R, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

[object Object]

Compounds are provided having the formula: wherein variables R, R, R, R, R, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Imidazolo-related compounds, compositions and methods for their use

NovelF-flourine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia, and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

CXCR3 antagonists

Compounds are provided that have the formula: where X, A, R, R, R, R, R, R, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use

Substituted pyrido[2,3-d]pyrimidines and methods for their use

Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Detection of hypoxia

Nitroaromatic compounds for the detection of hypoxia

Growing community of inventors

South San Francisco, CA, United States of America

An-Rong Li