Cairdac

Vermon

Vermon S.a.

Other

Commissariat À L'énergie Atomique Et Aux Énergies Alternatives

Université Grenoble Alpes

Sa Vermon

Cairdac S.a.s.

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie

Carthera S.a.s.

An Nguyen-Dinh

Willy Regnier

Alaa Makdissi

Aimé Flesch

Julien Dohin

Aim&eacute; Flesch

Rémi Dufait

Philippe Auclair

Nicolas Felix

Christophe Notard

Etienne Flesch

Bogdan Rosinski

Claire Bantignies

Hung Le Khanh

Thien Hoang

Steeven Vassal

Jean-Yves Chapelon

Alexandre Carpentier

Cyril Lafon

Skandar Basrour

Michael Canney

Françoise Chavrier

Jérôme Boutet

Cyril Meynier

Igor Bimbaud

Mathieu Debourdeau

Guillaume Férin

Pascal Mauchamp

William Apoutou N'Djin

Jean-Baptiste Pourchet

Emilie Trioux

Guillaume Ferin

R&eacute;mi Dufait

Leong Ratsimandresy

Elisabeth Lacaze

Libor Rufer

Odile Messineo

Aasim Khalid

Simon-Peter Santospirito

Christopher Spree

Stephane Michau

Perrine Chaffotte

Florian Leveque

Dominique Dinet

Guilaume Ferin

David Voisin

Martin Flesch

Guillaume FÉRIN

Remi Dufait

Aime Flesch

Mathieu Legros

William Apoutou N'djin

Marie-Coline Dumoux

The harvester comprises a pendular unit comprising a beam that is elastically deformable in bending, a mount clamping a proximal end of the beam, and an inertial mass mounted at a free, distal end of the beam. The beam converts into an oscillating electric signal a mechanical energy produced by pendular unit oscillations. The beam comprises a flexible structure including a central core, a piezoelectric layer on at least one face of the central core, and at least one surface electrode on an external face of the piezoelectric layer. The central core of the flexible structure is made of a semiconductor material adapted to form an integrated circuit substrate. The substrate made of a semiconductor material of the central core includes monolithic integrated structures, and the arrangement, over the extend of the central core substrate, of said integrated structures forms in the longitudinal direction a plurality of successive areas having different bending stiffness coefficients from an area to another.

Piezoelectric-transducer energy harvester, in particular for powering an autonomous cardiac capsule, with a bending stiffness gradient oscillating structure

An energy harvesting module includes a pendular unit with piezoelectric transducer elastically deformable in bending between a clamped end and a free end coupled to an inertial mass. The piezoelectric transducer includes two coplanar piezoelectric beams arranged side-by-side on either side of a central axis of the transducer, each of the piezoelectric beams including adjacent external and internal arms, arranged side-by-side and formed single-piece. The external arm of each beam has a clamped proximal end and a free distal end, and the internal arm of each beam has a free proximal end supporting the inertial mass, and a free distal end connected to the distal end of the adjacent external arm by a common junction.

Energy harvesting module with dual-cantilever piezoelectric transducer, in particular for powering a leadless autonomous cardiac capsule

An energy harvesting module includes a pendular unit with piezoelectric transducer elastically deformable in bending with a clamped end and a free end coupled to an inertial mass. The transducer includes at least one piezoelectric beam configured into two adjacent arms formed single-piece, with external and internal arms arranged side-by-side. The external arm has a clamped proximal end and a free distal end, and the internal arm has a free proximal end supporting the inertial mass, and a free distal end connected to the distal end of the adjacent external arm. An annular mount surrounds the beam at its proximal end and includes the clamp to which is fastened the proximal end of the external arm. The mount includes, in a central region in the vicinity of the clamp, a cavity inside which the inertial mass carried by the free proximal end of the internal arm can oscillate.

Energy harvesting module with compact-construction piezoelectric transducer, in particular for powering a leadless autonomous cardiaccapsule

The pendular unit comprises a piezoelectric transducer beam, and an inertial mass mounted at the free distal end of the beam and comprising two half-masses arranged on either side of the beam. A mechanical connection connects the two half-masses to each other on either side of the beam in such a way as to clamp the beam between the two half-masses to secure the inertial mass to the beam, the assembly being devoid of glue between the half-masses and the beam.

Pendular unit with an inertial mass mounted on a piezoelectric beam, in particular for an energy harvester in a leadless autonomous cardiac capsule

The module comprises, in an envelope tube, a pendular unit comprising a piezoelectric transducer, PZT, beam, an inertial mass coupled to the free end of the beam, and a beam mount secured to the tube and fastened to a clamping part of the beam. The module further includes a symmetrization insert for calibrating and symmetrizing the pendular unit oscillations in transverse and lateral directions. The symmetrization insert is distinct from the beam mount and comprises a peripheral portion secured to the tube independently of the beam mount, and a central portion with an axial through-cavity inside which the beam extends in said region of free travel. The axial cavity extends between opposite travel limitation surfaces, which are symmetrical and capable of coming into contact with the beam in a bending configuration of the beam.

Piezoelectric energy harvester with a controlled deflection beam, in particular for powering a leadless autonomous cardiac capsule

The device has a device body with a front face at its distal end, and a means for the anchoring of the medical device to a patient's organ wall. The anchoring means includes a screw with a helix wire wound into a plurality of non-contiguous turns, the screw having a clamped end integral with the front face of the device body and a free end with a beveled end defined by at least one oblique surface. The helix wire includes, at its free distal end, a terminal region whose wire bending stiffness is lower than in a proximal region of the helix turns. The stiffness difference may, in particular, be obtained by varying the wire diameter over different successive portions, with decreasing diameters in a proximal to distal direction.

Implantable medical device with a flexible helical anchoring screw

The device, such as an autonomous cardiac implant of the leadless capsule type, has a device body with a means for its anchoring to a patient's organ wall. The anchoring means includes a screw with a helix wire wound into a plurality of non-contiguous turns, the screw having a clamped end integral with the front face of the device body and a free end with a beveled end defined by at least one oblique surface. The normal to the oblique surface of the beveled end is directed away from the front face, in such a way that the oblique surface is directed towards the patient's organ wall. The normal to the oblique surface forms an angle between 30° and 60° with respect to the helix axis, and the screw is elastically deformable in axial compression, with a stiffness coefficient of at most 5 N/mm.

Implantable medical device with a non-traumatic helical anchoring screw

The instrument includes a dual-wall deformable tube, with an inner sleeve, a coaxial outer sleeve, and an imaging module connected to the inner and outer sleeves. An array of transducers is carried by an outer face of the imaging module. The inner sleeve and the outer sleeve are mobile in relative axial translation between: a folded position in which the inner and outer sleeves both have a cylindrical shape, and in which the imaging module substantially extends in the continuation of the inner sleeve; and an expanded position, in which the inner sleeve has a cylindrical shape and the outer sleeve has a flared shape widening on the distal side and in which the imaging module substantially extends with the face that carries the transducers of the array turned in axial direction towards the front of the deformable tube.

Catheter with built-in ultrasound imaging sensors

The implant comprises a tubular body housing an energy harvesting module adapted to convert external stresses applied to the implant into electrical energy, and a rechargeable battery adapted to be charged by the energy harvesting module. During the storage, an external source physically separated from the implant is coupled to the implant rechargeable battery to maintain a minimum battery charge level. An interface circuit of the implant couples surface electrodes to the battery, with switching between: i) a transport and storage configuration where the electrodes are connected to the external source to receive from the latter a battery charging energy and/or to exchange communication signals with the outside through the wire link of the coupling; and ii) a functional configuration in which the surface electrodes are decoupled from the external source after the implant has been implanted. The implant further comprises a data transmitter circuit adapted, in the transport and storage configuration, to send communication signals, via the surface electrodes, on the link coupling to the external source, and/or a data receiver circuit adapted, in the transport and storage configuration, to receive, via the surface electrodes, communication signals transmitted on the link coupling to the external source.

Autonomous cardiac implant of the leadless capsule type, comprising an interface for external communication during transportation and storage

The implant comprises a tubular body housing an energy harvesting module adapted to convert external stresses applied to the implant into electrical energy, and a rechargeable battery adapted to be charged by the energy harvesting module. During the storage, an external source physically separated from the implant is coupled to the implant rechargeable battery to maintain a minimum battery charge level. An interface circuit of the implant couples surface electrodes to the battery, with switching between: i) a transport and storage configuration where the electrodes are connected to the external source to receive from the latter a battery charging energy and/or to exchange communication signals with the outside through the wire link of the coupling; and ii) a functional configuration in which the surface electrodes are decoupled from the external source after the implant has been implanted. At least one of the implant surface electrodes is an auxiliary electrode that is not a cardiac potential detection/pacing electrode. In the transport and storage configuration, the interface circuit couple the auxiliary electrode to the implant rechargeable battery, and in the functional configuration, the interface circuit decouples the auxiliary electrode from the implant rechargeable battery and put the auxiliary electrode to a floating potential.

Autonomous cardiac implant of the leadless capsule type, comprising an auxiliary electrode for charging the battery by means of an external source during transportation and storage

This module comprises: a circuit for interfacing with the piezoelectric beam of an oscillating pendular unit, outputting a rectified signal comprising a sequence of pulses at a frequency equal to a multiple of the oscillation frequency of the pendular unit; a buffer capacitor charged by the successive pulses outputted by the interface circuit; and a converter regulator adapted to convert a capacitor discharge current into a stabilized power supply voltage, and controlled by a feedback control stage of the Maximum Power-Point Tracking (MPPT) type. A comparator detects the conduction of a blocking diode interposed between the interface circuit and the capacitor, in order to produce a signal representative of the current value of the duty cycle of the detected conduction and non-conduction periods. This signal is compared with a predetermined optimum duty cycle value in order to enable or disable the coupling of the capacitor to the converter regulator so as to control either the capacitor discharge towards an input of the converter regulator, or the continuation of its charging.

Optimized piezoelectric transducer-based energy harvesting module, in particular for charging the battery of an implantable medical device such as a leadless autonomous cardiac capsule

An integrated self-sustainable power supply includes a piezoelectric energy harvesting (PEH) beam, a power management unit (PMU) circuit located on the PEH beam, a rechargeable battery located on the PEH beam, and a positive regulated power supply output and a negative regulated power supply output. The PMU circuit includes electrical inputs/outputs. The rechargeable battery includes a negative access pad and a positive access pad, which are in electrical communication with the electrical inputs/outputs of the PMU circuit. The positive regulated power supply output and the negative regulated power supply output are also in electrical communication with the electrical inputs/outputs of the PMU circuit.

Integrated self-sustainable power supply

The capsule comprises a tubular body and a front-end unit with an helical screw for anchoring the capsule to a wall of a patient's organ. The front-end unit is mobile in relative axial rotation with respect to the tubular body. A disengageable frictional coupling member allows this relative rotation when, for implantation, the tubular body receives an external rotational stress, and that until a predetermined limit torque triggering the disengagement. At explantation, this disengagement is prevented to allow a joint rotation of the tubular body and of the front-end unit and the unscrewing of the helical screw. It is provided for that purpose two conjugated plates facing each other, with flat surfaces such as circular sectors offset in opposite directions with respect to a radial reference plane, in such a way as to form steps providing an anti-disengagement abutment function.

Autonomous implantable and removable cardiac capsule with a swiveling head and a torque limiter

The module comprises a pendular unit with an elastically deformable piezoelectric beam having a clamped end and an opposite, free end, coupled to an inertial mass. The beam produces an oscillating electrical signal collected by electrodes, which is rectified and regulated to output a voltage for charging a battery. The number and configuration of the electrodes (T, T, B, B, N) carried by the piezoelectric beam define a plurality of pairs of electrodes between which a corresponding plurality of said oscillating signals can be simultaneously collected. A switching matrix, as a function of an input command, selectively switches the plurality of pairs of electrodes between each other according to a plurality of different series (S), parallel (P) and/or series-parallel (SP) configurations, the selected configuration being that which maximizes the power sent to the battery as a function of the voltage level (VBAT) present at the terminals of the latter.

Piezoelectric transducer-based energy harvesting module, in particular for optimized charging of the battery of an implantable medical device such as a leadless autonomous cardiac capsule

A piezoelectric bimorph cantilever beam system includes a shim having a first main surface, a second main surface opposite the first main surface, a proximal end connected to an anchor, and a distal end opposite the proximal end. The system further includes a first piezoelectric layer laminated on the first main surface of the shim and a second piezoelectric layer laminated on the second main surface of the shim. A first beam stiffener is provided over the first main surface of the shim adjacent to the anchor with the first beam stiffener at least partially covering the first piezoelectric layer. A second beam stiffener is provided over the second main surface of the shim adjacent to the anchor with the second beam stiffener at least partially covering the second piezoelectric layer.

Piezoelectric energy harvesting bending structure and the method of manufacturing thereof

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La Riche, France

An Nguyen-Dinh