Il Dong Pharmaceutical Co., Ltd.

An-Na Moon

Kyung-Sun Kim

Dong-Keun Song

Yoon-Suk Lee

Jeong-Ah Kim

Ju-Young Jung

Sun-Young Park

Jeong-Geun Kim

Sung-Wook Kwon

Jun-Su Ban

Soo-Jin Lee

Sung-Ku Choi

Kyu-Sic Jang

The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Autotaxin inhibitor compounds

Adenosine receptor (e.g., A2A and/or A1 receptor) antagonist compounds and compositions including said compounds are disclosed. The present disclosure also provides methods of using said compounds and compositions for modulating (e.g., inhibiting or antagonizing) A2A and/or A1 receptor in a biological system. The compounds and compositions find use in various therapeutic applications including the treatment of central nervous system or neurodegenerative diseases, such as Parkinson's disease. The compounds and compositions may also find use in various therapeutic applications including the treatment of cancer and in immuno-oncology.

Prevention and/or treatment of CNS disorders

Growing community of inventors

Hwaseong-si, South Korea

An-Na Moon