The Rockefeller University

Intelect Medical, Inc.

Amy Wells Quinkert

Scott Kokones

Bradford Curtis Fowler

Donald Pfaff

Methods, apparatuses, and software for operating such apparatuses, for neuromodulation in a live mammalian subject, such as a human patient, provide for applying electrical energy to a target site in the nervous system of the subject using a signal comprising a series of pulses, wherein the inter-pulse intervals are varied using the output of a deterministic, non-linear, dynamical system comprising one or more system control parameters. In certain embodiments, the target site may be a site in the brain involved in generalized CNS (central nervous system) arousal. The dynamical system may be capable of exhibiting chaotic behavior.

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New York, NY, United States of America

Amy Wells Quinkert