Wyeth

Wyeth Holdings Corporation

Amy Wadhams Masi

Bruce Arthur Green

Robert J Zagursky

Joseph Lawrence Wooters

David Parrish Russell

Deb Narayan Chakravarti

The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of, wherein the open reading frames encode polypeptides that are surface localized on. Thus, the invention relates toopen reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by theopen reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosinginfection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by

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The present invention discloses amino acid sequences and nucleic acid sequences relating to asurface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to reduce colonization of pneumococcal bacteria. Thus the present invention also pertains to compositions for the treatment and prophylaxis of infection or inflammation associated with bacterial infection.

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Caledonia, NY, United States of America

Amy Wadhams Masi