Wyeth

Other

Millennium Pharmaceuticals Limited

Amy Szepui Tam

Mark L Stahl

William Stuart Somers

Kevin Delos Parris

Laura Lin

Robert L Powers

Guang-Yi Xu

Laura Long Lin

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure ofACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Crystals of an acyl carrier protein synthase/acyl carrier protein complex

This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.

Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Methods for identifying agents that interact with an active site of acyl carrier protein synthase-acyl carrier protein complex

Growing community of inventors

Medford, MA, United States of America

Amy Szepui Tam