3m Innovative Properties Company

Radius Health, Inc.

3m Innovative Properties Company, a Wholly Owned Subsidiary of 3m Company

Amy S Determan

Robert A Asmus

Jason W Bjork

Jonathan J O'Hare

James Patrick DiZio

Zhicheng Tian

Matthew T Scholz

Jeffrey O Emslander

James P DiZio

Gary Hattersley

Joan T Moseman

Peter R Johnson

Korey W Karls

Ryan T Woldt

Ying Zhang

Kristen J Hansen

Kris J Hansen

Jonathan J O'HARE

Kirsten J Hansen

Provided is a method of forming a fibrin hydrogel composition, the method including providing a fibrin hydrogel or precursor thereof, comprising fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further includes combining the fibrin hydrogel with a carrier material. The concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrin hydrogel.

Fibrin composition comprising carrier material, method and wound articles

Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.

Fibrinogen composition, method and wound articles

Multilayer articles having an absorbent nonwoven layer and a barrier layer are described, including those having a surfactant-treated, aliphatic polyester, nonwoven absorbent layer and a barrier layer. Multilayer articles including a tie layer used to enhance the bond between the hydrophilic absorbent layer and the barrier layer are also described. Methods of making and using such articles are also described.

Multi-layer articles

Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25&#xb0; C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50&#xb0; or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.

Aqueous formulations for coating microneedle arrays

Growing community of inventors

Mahtomedi, MN, United States of America

Amy S Determan