Mallinckrodt Hospital Products IP Limited

Mallinckrodt Pharmaceuticals Ireland Limited

Therakos, Inc.

Amy Krutsick

David Peritt

Kim Campbell

Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell ('APC'), has a high capacity to do so. The recognition of apoptotic cells ('ACs') occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (&#x201c;ACAMPRs&#x201d;) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (&#x201c;ACAMPs&#x201d;). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).

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Chester Springs, PA, United States of America

Amy Krutsick