Roche Palo Alto LLC

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Amy Geraldine Moore

Michael Patrick Dillon

Alam Jahangir

Clara Jeou Jen Lin

Yansheng Zhai

Ronald Charles Hawley

Matthew C Lucas

Francisco Xavier Talamas

Sharada Shenvi Labadie

Chris Allen Broka

Shaoqing Chen

Johannes Cornelius Hermann

David Scott Carter

Andreas Kuglstatter

Jutta Wanner

Nidhi Arora

Daniel Warren Parish

Anthony P D W Ford

Eva Papp

Counde O'Yang

Paul J Wagner

Clara Jeou Lin

Anthony Pdw Ford

Anthony PDW Ford

Compounds of the formula I or II: wherein X, m, Ar, Rand Rare as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

[object Object]

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,

Shoestring

Compounds and methods for treating diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R, R, R, R, R, R, Rand Rare as defined herein.

This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:wherein m, A, X, Y, R, R, R, Rand Rare as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

Method for detecting a gram-negative bacterial autoinducer molecule

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Mountain View, CA, United States of America

Amy Geraldine Moore