Harbor Branch Oceanographic Institution, Inc.

Other

Florida Atlantic University

University of California

University of Central Florida Research Foundation, Inc.

Amy E Wright

Shirley A Pomponi

Ross E Longley

Peter J McCarthy

Robert S Jacobs

Sarath P Gunasekera

Richard A Isbrucker

John K Reed

Ying Hai Chen

Neal S Burres

Winnie C Thompson

Esther A Guzman

Sue S Cross

Frank Koehn

Ralph-Heiko Mattern

Jacob D Johnson

Jennifer L Cummins

Glynn Thomas Faircloth

Claude P Selitrennikoff

Debopam Chakrabarti

May S Lui

Susan H Sennett

Gopal K Paul

Srinivasa Reddy Natala

Jill Roberts

Claudia E Moya

Dedra Harmody

Keith Brian Killday

K Brian Killday

Katherine Chilson

Rebecca Schimoler

David Langley

Paul Stead

Sarath P Gunaskera

Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.

Anti-malarial compounds from marine natural products

Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.

Use of manzamine compounds in anti-cancer therapeutic regimens

The subject invention provides novel compositions of biologically active compounds which can advantageously be used in blocking cellular proliferation and/or treatment of cancer. Exemplified are: 

Biologically active aphrocallistin compounds

The subject invention provides novel biologically active compounds that have utility for use in inhibiting cellular proliferation. Pharmaceutical compositions comprising these compounds are also provided. In a specific embodiment, the compounds and compositions of the subject invention can be used in the treatment of cancer.

Antiproliferative activity of the leiodermatolide class of macrolides

The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Biologically active lasonolide compounds

Biologically active neopeltolide compounds

The subject invention provides novel compositions of biologically active polyketide compounds that can advantageously be used in blocking cellular proliferation and treatment of cancer.

Biologically active raspailamide compounds

The subject invention provides novel compositions of biologically active compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.

Lactone compounds and methods of use

The subject invention provides novel compositions of biologically active linderazulene terpene compounds which can advantageously be used for treating cancer and stopping cell proliferation.

Biologically active linderazulene terpenes

The subject invention provides novel compositions of biologically active discorhabdin compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.

Discorhabdin compounds and methods of use

The subject invention provides novel compositions of biologically active glycosylated pregnene compounds which can advantageously be used for treating cancer and stopping cell proliferation.

Biologically active pregnene compounds

Dictyostatin-1 has been found to stabilize microtubules and prohibit their depolymerization to free tubulin. Because of these activities, the dictyostatin compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.

Compositions and uses of dictyostatin compounds

The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed bis-heterocyclic compounds. Specifically exemplified herein are dragmacidin f, topsentin d, and topsentin e, and their salts, analogs, and derivatives.

Compounds and methods of use for treatment of neurogenic inflammation

Growing community of inventors

Fort Pierce, FL, United States of America

Amy E Wright