Cell Design Labs, Inc.

Kite Pharma, Inc.

Amy E Gilbert

Peter Emtage

Anselm Levskaya

Vladimir Anatolievich Slepushkin

Spencer Scott

Matthew Drever

Samuel T Haile

Catherine A Hartzell

The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, and specifically to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors.

Methods and compositions for reducing the immunogenicity of chimeric notch receptors

Provided are antibodies, fragments thereof, chimeric antigen receptors (CARs) and T cell receptors (TCRs) comprising one or more of the anti-PMCA antigen binding domains disclosed herein. SynNotch receptors that comprise an anti-PSCA binding domain Provided are polynucleotides encoding antibodies, fragments thereof, CARs, T cell receptors (TCR) and SynNotch receptors. Provided are compositions, cells and cell therapies comprising the same. Further provided are methods of treatment.

Prostate cancer chimeric antigen receptors

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San Francisco, CA, United States of America

Amy E Gilbert