Rutgers, the State University of New Jersey

Uropharma Limited

Synesis LLC

Amy B Howell

Nicholi Vorsa

Christian Gerald Krueger

Jess Dreher Reed

Scott Glickman

Howard Shapland

Jess D Reed

Christian G Krueger

Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and/or liposomes containing an anti-cancer agent, together with compositions related thereto.

Medicinal composition for treating urinary tract infection (UTI)

The present invention is directed to isolation and identification of plant proanthocyanidin extracts and particular proanthocyanidin compounds for prevention and treatment of urinary tract infections caused by P-type . These extracts can be obtained from any proanthocyanidin-containing plants, including plants of the families Ericaceae, Rosaceae, Pinaceae, Vitaceae and the like. Preferably the extracts are from cranberry plants (especially, ) and other plants, particularly fruit and berry plants from the Vaccinium spp. The extracts and compounds are also provided as pharmaceutical compositions, food additives and food compositions, especially beverages, ground meat preparations and cranberry-containing food products. The invention also relates to methods of reducing pathogenicity of P-type in the digestive tracts of cattle and reducing P-type contamination in ground meat as well as methods of detecting P-type bacteria.

Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces

Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with P-type fimbriae to surfaces

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Hammonton, NJ, United States of America

Amy B Howell