Sri International

David Sarnoff Research Center, Inc.

Leland Stanford Junior University

Sarnoff Corporation

New York Medical College

Amrit K Judd

Doris J Bucher

Peter John Zanzucchi

Satyam Choudary Cherukuri

Sterling Edward McBride

Lawrence Steinman

Gary K Schoolnik

Allan J Johnston

Jorge R Oksenberg

Steven W Popple

Pepi Ross

A method of making a dielectric substrate array for conducting a plurality of reactions in parallel in a number of wells, the method comprising: forming a first passage and a second passage each extending through a dielectric substrate, the substrate having a first surface and an opposing second surface; forming a plurality of channels on said first or second surface, including a first channel, a second channel, a third channel and a fourth channel on the substrate, wherein the first channel is on the first surface and intersects with the first passage, wherein the second channel is on the second surface and intersects with both of the first passage and the second passage, wherein the third channel is on the first surface and intersects with the second passage, wherein the fourth channel is on the first surface and is located between the outlets of the first and second passage at the first surface, and wherein (a) the connected first channel, first passage, second channel, second passage and third channel define a cross-over channel having dimensions suitable for promoting capillary action and (b) the fourth channel defines another channel having dimensions suitable for promoting capillary action; forming a plurality of reservoirs in a surface of the substrate, each connected to a channel, with one of the reservoirs connected to the first channel; and bonding a first plate to the top surface of the substrate and a second plate to the bottom surface of the substrate, thereby enclosing the channels, wherein the cross-over channel crosses over from the first surface to the second surface via the first passage and back to the first surface via the second passage and thereby avoids intersecting with the fourth channel located on the first surface.

Partitioned microelectronic device array

Methods are provided for synthesizing a plurality of compounds in parallel. The methods use cross-over channels for moving samples from a reservoir of starting materials into a plurality of wells. The movement is achieved, for example, using an electrokinetic pump.

Method of synthesis of plurality of compounds in parallel using a

Peptides substantially corresponding to the 148-162 region of type A influenza M protein and additionally containing at least one amino acid in the 163-166 region are disclosed to have high activity as influenza transcription inhibitors and thus as antiviral agents against influenza virus and other RNA viruses. The modification of these peptides by incorporation into liposomes or by addition of long-chain alkylamino acids is also shown as in the use of all such materials in antiviral drug formulations.

M-protein peptides of influenza virus as antiviral agents

A system for processing a plurality of tests or syntheses in parallel comprising a sample channel for moving samples into a microlaboratory array of a plurality of wells connected by one or more channels for the testing or synthesis of samples, a station for housing the array and an optical system comprising at least one light source and at least one light detector for measuring the samples in the array, and a means of electrically connecting said array to an apparatus capable of monitoring and controlling the flow of fluids into the array. Samples are loaded from a common loading channel into the array, processed in the wells and measurements taken by the optical system. The array can process many samples, or synthesize many compounds in parallel, reducing the time required for such processes.

Macromolecular conjugates of a synthetic polypeptide having influenza virus antigenic properties are disclosed. These conjugates contain a polypeptide corresponding substantially to the 215-235 region of the matrix protein (M-protein) of influenza virus.

Conjugates of a synthetic peptide for diagnosis and prevention of

Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to the 215 to 235 region of the matrix protein of influenza virus. Salts, derivatives, and conjugates of these polypeptides are disclosed as well as methods for using these materials for diagnostic and medical/veterinary purposes.

Synthetic peptides for diagnosis and prevention of influenza virus

An apparatus for simultaneously performing a multiplicity of synthesis reactions is disclosed. The synthesizer includes at least one reaction vessel having an access port and a synthesis compartment adjacent the access port. A closable exit channel with an exit port is adjacent the synthesis compartment. The apparatus also includes a base having a plurality of inlets, each of the inlets configured to receive the exit channel of the reaction vessel. A fluid outlet is present that is in communication with the plurality of inlets. A vacuum pump and vacuum line are connected to the fluid outlet for sucking excess reagents and by-products from the reaction vessel. The apparatus further includes a shaker for shaking the reaction vessel while synthesis is proceeding.

Multiple polymer synthesizer

A novel method of defining oligopeptides is provided for determining useful immunodominant sequences for use as vaccines for pathogens. The method involves identifying sequences by particular selection procedures and using such sequences with antigen-presenting cells and T-cells to demonstrate activation of the common histocompatibility antigens DQ and DR in humans and their analogs in other animals. The oligopeptides may then be used individually or in combination to produce safe and effective vaccines, where genes may be prepared encoding the oligopeptides and used for expression of the oligopeptides or combinations of the oligopeptides or the gene transformed into the appropriate host, e.g., B. pertussis, for use as a vaccine to the intact organism.

Polypeptide pertussis toxin vaccine

Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to particular regions in the matrix protein of influenza virus. Salts, derivatives, and conjugates of these polypeptides are disclosed as well as methods for using these materials for diagnostic and medical/veterinary purposes.

The present invention provides a stabilized potassium ion-selective membrane comprising lysine-substituted valinomycin covalently bound to a polymeric substrate. The membrane of the invention exhibits improved stability and is used either on ISEs or on solid-state coated wire or semiconductor devices.

Growing community of inventors

Belmont, CA, United States of America

Amrit K Judd