The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland

Domantis Limited

Amrik Basran

Steve Holmes

Ian M Tomlinson

Carolyn Enever

Neil C Bruce

Benjamin P Woolven

Jennifer A Lee

Christopher Edward French

Stephen Nicklin

Neil D Brewis

Kate Jones

Ruud De Wildt

Stanislas Blein

Emma Rachel Travis

Stanislas Charles Blein

The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.

Antagonists against TNFR1 and methods of use therefor

An enzymically active cell free extract or membrane fraction capable of catalysing the removal of nitrite from hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is provided. The cell free extract is produced by culturing a strain of,bacterium from nature. The strain designated 11Y has been deposited as NCIMB 40820. Methods of bioremediation using the enzymically active cell free extract so produced are also provided. Additionally there is provided a method for detecting the presence of RDX in a sample together with a biosensor for use in such a method. The nitrite produced in the enzyme catalysed reaction with RDX is detected, for example, colorimetrically, or alternatively a product of RDX degradation, such as formal behyde, is detected.

Biodegradation of explosives

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Cambridge, United Kingdom

Amrik Basran