Lightlab Imaging, Inc.

Ormco Corporation

Dental Imaging Technologies Corporation

Amr Medhat Elbasiony

Joel M Friedman

Joseph M Schmitt

Christopher Petroff

Robert F Dillon

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Lumen morphology and vascular resistance measurements data collection systems apparatus and methods

In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.

Calibration and image processing devices, methods, and systems

An imaging system, a method for imaging an object of interest, and an image of the object of interest. In one embodiment, an imaging system includes a channel configured to receive information from an object of interest, a 3DSS sub-system configured to capture information from the object of interest and generate at least one of 3D surface data or 3D position data based on the information captured by the 3DSS sub-system, and an OCT sub-system configured to perform a line scan of light reflected from the object of interest, generate OCT image data from the line scan, receive the at least one of the 3D surface data or the 3D position data, and generate one or more OCT images using the OCT image data and the at least one of the 3D surface data or the 3D position data.

Optical coherence tomography imaging system

Optical coherence tomography lumen morphology and vascular resistance measurements methods for blood vessel evaluations

In part, the invention relates to computer-based methods, devices, and systems suitable for displaying stent malapposition in a 2-D or 3-D image. A threshold malapposition distance can be set as an input in response to which a software component in an imaging pipeline automatically detects stent struts and calculates a malapposition distance from a lumen contour. Projections of stent strut dimensions can be used to compensate for stent imaging artifacts results from imaging probe orientation in the lumen.

Stent visualization and malapposition detection systems, devices, and methods

Lumen morphology image reconstruction based on the scan line data of OCT

In one embodiment, the invention relates to a method of detecting a side branch for a vessel scanned using a probe. The method includes storing optical coherence image data obtained during a pullback through the vessel in a memory device, the optical coherence image data comprising a plurality of frames; identifying a first region having a first intensity in a first frame of the plurality of frames; identifying a second region having a second intensity in the first frame of the plurality of frames; identifying a third region having a third intensity in the first frame of the plurality of frames; comparing the first intensity to the second intensity; comparing the third intensity to the second intensity; and generating an output characterizing the second region as a candidate side branch when the first intensity and the third intensity are both greater than the second intensity.

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Chelmsford, MA, United States of America

Amr Medhat Elbasiony