Becton Dickinson and Company Limited

Bd Kiestra B.v.

Bd Diagnostics

Ammon David Lentz

Dwight Livingston

Adam Bruce Steel

Richard St Pierre

Mark A Talmer

Robert L Campbell

Michael Justin Lizzi

Melody M H Kuroda

Thomas D Haubert

James A Prescott

Michael L Marshall

Gregory S Kramer

Scott Nicholas Danhof

M Scott Ulrich

Randy J Somerville

Dustin Diemert

Kevin Bailey

Gary F Hershner

Alyssa Shedlosky

Timothy Roy Hansen

Joel Daniel Krayer

Mark Anthony Messina

Laurence Michael Vaughan

Elisabeth Lily Sooklal

Joseph Kelleher

Sharon Virginia LaMont Leitch

Daniel Justin Lohan

Thomas Paul Borgoyn

Brent Ronald Pohl

Ming-hsiung Yeh

Artis R Lockhart

Andrea Liebmann-Vinson

John Thulin Page

Kevin G Dolan

Ernie Ritchey

Wendy Dale Woodley

Jack H Kessler

Michael A Brasch

Timothy M Wiles

Ming-Hsiung Yeh

Charles C Yu

Patrick Shawn Beaty

Robert Edward Armstrong

Mei Yang-Woytowitz

Adam C Curry

Kristin Weidemaier

Ben Turng

Liping Feng

Eric Fallows

David S Sebba

Donald E Gorelick

Miroslaw Bartkowiak

Robert Michael Novak

Jack Kessler

Spencer Lovette

Scott N Danhof

Franciscus Feijen

Xiaofei Chang

Eric Ursprung

John Thuin Page

Patrick R Murray

Erin Gooch Carruthers

Gerard Lotz

Brent D Ludwig

Richard St-Pierre

Allan M Kiang

Jeffrey S Ojala

Melody Mh Kuroda

David S Sebra

Eric A Fallows

Melody MH Kuroda

A method for penetrating a pierceable cap () on a vessel (). The pierceable cap () prevents escape of sample specimens from the vessel () before transfer with a transfer device (). The pierceable cap () may fit over a vessel (). An access port in the shell of the pierceable cap () may allow passage of a transfer device () through the pierceable cap (). At least one frangible layer () may be configured with cross slits () in a particular cross slit geometry. The cross slits () may contain an openable portion () or be covered by a thin membrane (). The shell () and frangible layer(s) () may be integrated into a one piece cap (), or be separate components (). The membrane on which the cross slitsare placed can be flat or contoured to guide the transfer device () to the cross slits (). The flat surfaces are supported by rib structures () that extend radially inward and downward into the vessel ().

Pierceable cap

A multi-port disposable device that can both vent a sealed culture vessel and draw a sample therefrom into a collection vessel. The multi-port disposable device has a first port configured to receive the top portion of a culture vessel and attach thereto. The multi-port disposable device has a second port configured to receive a sample collection vessel. The multi-port disposable device has first and second needles. The first needle has a cannula configured to penetrate a septum or cap of the culture vessel. Optionally, the cannula terminates in a layer of foam that carries a microbial agent such that any vapor that is transmitted from the culture vessel through the cannula when venting the sealed culture vessel is absorbed by the foam. Optionally, the ports of the disposable device are configured as sleeves. The sleeve of the first port receives a portion of the culture vessel and the sleeve of the second port receives the collection vessel. The second needle has a cannula that penetrates both the septum or cap of the culture vessel and the septum or cap of the collection vessel, when the culture vessel and the collection vessel are brought into the device, thereby providing for fluid communication between the culture vessel and the collection vessel. The second cannula provides the flow pathway for delivering sample from the culture vessel to the collection vessel.

Disposable device for venting a sealed container and aliquoting therefrom

A pierceable cap may be used for containing sample specimens. The pierceable cap may prevent escape of sample specimens before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the shell of the pierceable cap may allow passage of a transfer device through the pierceable cap. The shell receives a septum that has four half dome indentations, each indentation defining a quadrant of the septum interior. The indentations are separated by the septum floor which extends along respective first and second diameters of the septum and intersect at approximately ninety degrees. The half dome indentations guide a transfer device to the partially slitted portion of the septum floor.

Reclosing septum cap for medical sample transport and processing

Microfluidic cartridge

Single piece reagent holder

An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel, a vessel insert, and a cap element. The vesselhas a body portionfor receiving a biological sample. The vessel insertreceives at least one reagent therein. Preferably, the vessel insertis received in a portionof the vessel. The cap elementis attached to the vesselto secure the vessel insertin the vessel. During use, the vessel insertis adapted to release its contents when the biological sample is introduced into the body portionof the vesselupon application of an intermixing force to the vessel insert. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Blood culture bottles with mechanisms for controlled release of substances into culture media

Sample rack adapter

A pierceable capmay be used for containing sample specimens. The pierceable capmay prevent escape of sample specimens before transfer with a transfer device. The pierceable capmay fit over a vessel. An access port in the shell of the pierceable capmay allow passage of a transfer devicethrough the pierceable cap. At least one frangible layermay be configured with cross slitsin a particular cross slit geometry. The cross slitsmay contain an openable portionor be covered by a thin membrane. The shelland frangible layer(s)may be integrated into a one piece cap, or be separate components. The membrane on which the cross slitsare placed can be flat or contoured to guide the transfer deviceto the cross slits

Vessel assembly

Various embodiments of the present disclosure describe systems and methods for testing samples (e.g., biological samples, environmental samples, food samples etc.) for microbial contamination. For example, some embodiments describe an adapter assembly with a means to penetrate a septum of a collection vessel and permit gaseous communication between a headspace of the collection vessel and a sensor. In some embodiments, the gases in the headspace of the collection vessel can exit the collection vessel without contaminating the environment outside the system or allowing sample contamination. In some embodiments, the adapter assembly includes a membrane configured to prevent liquid in the collection vessel from contacting the sensor. In some embodiments, the adapter assembly can be used to access media inside the collection vessel for subculturing or aliquotting for another diagnostic process such as molecular diagnostics.

Adapter assembly for attachment to a bottle

Combined cap and septum assembly for a vessel

Septum for a vessel

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

Growing community of inventors

York, PA, United States of America

Ammon David Lentz