Acucela Inc.

Adlens Beacon, Inc.

Pogotec, Inc.

Onefocus Vision, Inc.

Johnson and Johnson Vision Care, Inc.

Mitsui Chemicals, Inc.

Essilor International (compagnie Generale D'optique)

Pixeloptics, Inc.

Other

Innotech Corporation

Oculeve, Inc.

Elenza, Inc.

Greatbatch Ltd.

Johnson & Johnson Vision Products Inc.

Essilor International

Amitava Gupta

Urban Schnell

Ryo Kubota

Karim Haroud

Ronald D Blum

Jean-Noel Fehr

William Kokonaski

Stefan Bauer

Julien Sauvet

Lisa A Nibauer

William Egan

Richard Clompus

Hans Jaeger

Steven B Waite

Patrizia Weber

Hans Bernhard

Matthew Peterson

Daniel Senatore

Jean-Noël Fehr

Frank Stangota

Bruce Decker

Stefan Troller

Massimo Pinazza

Claudio Dalla Longa

Jean-Christophe Roulet

Walter Dannhardt

Beat Wyss

Pascal Loser

Thomas M McGuire

Edgar V Menezes

Vance Michael Thompson

Philip M Buscemi

Moritz Haeberli

Douglas P Adams

C Benjamin Wooley

Jonathan Paul Downing

Michel Saint-Ghislain

Christian Oggenfuss

Gamil Alhakimi

Lisa Studnicki

Steve Waite

Musa Alhakimi

Adam Harant

Ferry Widjaja

Benjamin Crook

Ronald David Blum

F Richard Christ

Venkatramani S Iyer

Neil Brian Cramer

Glenn Noronha

William J Link

Marie Dvorak Christ

Amelia Davenport

Bobi Arnold

James Donald Loudin

Matthias Pfister

Stephan Wyder

Richard J Nason

Paul J Nagg

John L Wardle

Joshua N Haddock

Joey Y Chen

Rudy A Mazzocchi

Brian Robert Peterson

Ivan M Nunez

Susan W Neadle

Anand Doraiswamy

Israel Grossinger

Leslie I Halberg

Timothy R Poling

Steven Wade Hamblin

Anita Trajkovska-Broach

Pierre Y Gerligand

Sean P McGinnis

Patrick Reardon

Marko Theodoor Blom

Venkat Sekharipuram

Sheila B Hickson-Curran

Thomas R Karkkainen

Gordon Frederick Maccabee

Arkady Selenow

Russell A Chipman

Walter Doll

Shyamy Sastry

Nabin Joshi

Roland Michaely

Christopher William Stivers

Ronny Van 't Oever

Jeroen Haneveld

Johannes Oonk

Alain Saurer

Ronald J Clark

Steven Ali

Joseph A Bishop

Marinus Bernardus Olde Riekerink

Eric Dogan

James S Merritt

Jose Ulloa

Peter Tijssen

An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters ('D') to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10to 2.5×10cycles per degree.

Projection of defocused images on the peripheral retina to treat refractive error

A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

Device for projecting images on the retina

A meniscus shaped lens module comprises one or more structures that decrease an amount of pressure or force to move one or more surfaces of the lens module and increase a separation distance of anterior and posterior surfaces of the module in order to provide an increase in optical power. A lens structure of the module comprises one or more of a pattern of a surface of a central chamber, a meniscus, a reduced diameter or a soft material in order to provide increased amounts of curvature of an outer contact lens surface with decreased amounts of pressure. The pattern can be formed in one or more of many ways, and may comprise one or more of folds, patterning, bellows or concertinaed surface of an optically transmissive material having a substantially uniform thickness such as a sheet of a membrane material.

Fluidic module for accommodating soft contact lens

A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

Method and apparatus for treating refractive error of the eye

An accommodating contact lens comprises a variable focus optical module, which comprises an optical chamber and one or more eyelid engaging chambers coupled to the optical chamber with one or more extensions comprising channels extending between the optical chamber and the more eyelid engaging chambers. The module may comprise a self-supporting module capable of supporting itself prior to placement in a contact lens to facilitate placement prior to encapsulation in the contact lens. The module may comprise one or more optically transmissive materials, provides improved optical correction, and can be combined with soft contact lens materials such as hydrogels. In many embodiments, the module comprises a support structure extending between an upper membrane and a lower membrane in order to provide variable optical power accurately with decreased amounts distortion and improved responsiveness to eyelid induced pressure.

Accommodating soft contact lens

A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

Optical designs of electronic apparatus to decrease myopia progression

A lens for refractive tear shaping, including a curved lens body defining an anterior partial thickness cavity indented into its anterior surface. The anterior partial thickness cavity has an anterior facing tear shaping surface structured to form a tear lens within the anterior partial thickness cavity. The anterior partial thickness cavity is structured to define a tear lens within the anterior partial thickness cavity by interaction between a tear film of the eye and the anterior facing base tear shaping surface. The posterior curvature of the tear lens is dependent on the shape of the anterior facing base tear shaping surface.

Tear shaping for refractive correction

Implantable pressure sensors and implantable electronics should be packaged in hermetically sealed modules with biocompatible surfaces before being implanted. Packaging designs should be compact and cause little to no interference with the mechanical (and optical) properties or functions of the implant. For a pressure sensor in an intraocular lens, this means that the sensor and packaging should allow the lens to be folded so that it can be implanted through a small incision in the eye. An inventive implantable pressure sensor is coated with a silicone elastomer and hermetically sealed by a multilayer coating of SiOand Parylene C, which may also encapsulate other components, including a microcontroller or processor, rechargeable batteries, sensors, resistors, capacitors, wireless transceivers, and/or antennas mounted on a transparent substrate. This combination of silicone gel and multilayer coating isolates the pressure sensor from surrounding tissue while allowing the pressure sensor to measure pressure precisely and quickly.

Implantable devices with embedded pressure sensors

A lens comprises an internal cavity structure formed by dissolution of a soluble insert material. The internal soluble material may dissolve through a body of a lens such as a contact lens in order to form the cavity within the contact lens. The cavity within the lens can be shaped in many ways, and corresponds to the shape of the dissolved material, such that many internal cavity shapes can be readily fabricated within the contact lens. The insert can be placed in a mold with a pre-polymer material, and the pre-polymer material cured with the insert placed in the mold to form the lens body. The polymerized polymer may comprise a low expansion polymer in order to inhibit expansion of the lens when hydrated. The polymer may comprise a hydrogel when hydrated. The soft contact lens material comprises a sufficient amount of cross-linking to provide structure to the lens and shape the cavity.

Accommodating lens with cavity

A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens

An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

Stick on devices using peripheral defocus to treat progressive refractive error

A lens for refractive tear shaping, including a curved lens body defining a central cavity indented into its posterior surface. The central cavity has a posterior facing tear shaping surface structured to form a tear lens within the central cavity. The central cavity is structured to define a tear lens within the central cavity by interaction between a tear film of the eye and the posterior facing tear shaping surface. The anterior curvature of the tear lens being dependent on the shape of the tear shaping surface.

A lens comprises an internal cavity structure formed by dissolution of a soluble insert material. The internal soluble material may dissolve through a body of a lens such as a contact lens in order to form the cavity within the contact lens. The cavity within the lens can be shaped in many ways and corresponds to the shape of the dissolved material, such that many internal cavity shapes can be readily fabricated within the contact lens. The insert can be placed in a mold with a pre-polymer material, and the pre-polymer material cured with the insert placed in the mold to form the lens body. The polymerized polymer may comprise a low expansion polymer in order to inhibit expansion of the lens when hydrated. The polymer may comprise a hydrogel when hydrated. The soft contact lens material comprises a sufficient amount of cross-linking to provide structure to the lens and shape the cavity.

Accommodating cavity lens shaped with photocleavable insert

An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

Electro-switchable spectacles for myopia treatment

Growing community of inventors

Roanoke, VA, United States of America

Amitava Gupta