Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Collplant Ltd.

Amit Yaari

Oded Shoseyov

Hanan Stein

Or Dgany

Helena Magrisso

Tamar Haya Tal

Michal Rosenthal

Zohar Katz

Tzvi Zvirin

A method of modifying a glycosylation pattern of a polypeptide-of-interest in a plant or plant cell is provided. The method comprising expressing in a plant or plant cell transformed to express at least one glycosidase in a subcellular compartment, a nucleic acid sequence encoding the polypeptide-of-interest, such that the at least one glycosidase and the polypeptide-of-interest are co-localized to the subcellular compartment of the plant or plant cell, thereby modifying the glycosylation pattern of the polypeptide-of-interest in the plant or plant cell.

Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells

A method is disclosed that exploits the combined features of carbohydrate binding modules (CBM) and nanocrystalline cellulose (CNC) for 'fishing out' specific agents of interest (AOI), such as proteins, which are optionally present or produced in culture.

Purification of an agent of interest

A method of generating a collagen fiber is disclosed. Fibers generated thereby are also disclosed as well as scaffolds comprising such fibers.

Method of generating collagen fibers

A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.

Growing community of inventors

Kibbutz Ein Dor, Israel

Amit Yaari