Genentech, Inc.

Exelixis, Inc.

Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Amit Srivastava

Jason Yang

C Gregory Sowell

Nathan Guz

Sriram Naganathan

Matthew Pfeiffer

Tracy Bostick

Neel Kumar Anand

Thomas Johannes Woltering

Juergen Wichmann

Paul Spurr

Stephan Bachmann

Stefan Hildbrand

Pingsheng Zhang

Sandeep Yadav

Miall Cedilote

Zhiming Dong

Doreen Miller

Anthony Tomlinson

Jodie Brice

Tamanna Shobha

Nidhi Doshi

Daniel Bailey

Pingsheng Zhan

The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.

Polysorbate mixtures having modified fatty acid ester distribution

Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Process for making compounds for use in the treatment of cancer

The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities. 

Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine

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Aiken, SC, United States of America

Amit Srivastava