Arcturus Therapeutics, Inc.

Amit Sagi

Priya Prakash Karmali

Yanjie Bao

Padmanabh Chivukula

Kiyoshi Tachikawa

Daiki Matsuda

Jared Henry Davis

Sean Michael Sullivan

Carlos G Perez-garcia

Jerel Boyd Lee Vega

Rajesh Mukthavaram

Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Coronavirus vaccine compositions and methods

Methods of preparing lyophilized lipid nanoparticle-nucleic acid compositions are provided. The methods comprise preparing a suspension of lipid nanoparticles with a monosaccharide and one or more excipients selected from thiosulfate, potassium sorbate, sodium benzoate, and iodixanol. Lyophilized lipid nanoparticle-nucleic acid compositions and methods of reconstituting and administering the same are further provided.

Method of lyophilizing lipid nanoparticles

Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.

Nucleic acids and methods of treatment for cystic fibrosis

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San Diego, CA, United States of America

Amit Sagi