General Electric Company

Lockheed Martin Corporation

Ge Healthcare Limited

Amit Mohan Kulkarni

Andrew Soliz Torres

Peter John Bonitatibus, Jr

Robert Edgar Colborn

Matthew David Butts

Bruce Allan Hay

Brian Christopher Bales

Michael Ernest Marino

Paul William Buckley

Ying Zhou

Daniel Eugene Meyer

Xiaogang Wang

Giri Kuthethoor

Orhan Cagri Imer

David Cheney deMoulpied

Anshul Kantwala

Michacl Ernest Marino

Chiaki Treynor

Richard Spackmann

Peter John Bonitatibus Jr

Brian C Bales

David Demoulpied

Jr Peter Bonitatibus

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Nanoparticle contrast agents for diagnostic imaging

The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.

Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same

A system and method are provided for implementing performance improvements in a multicast protocol for networks that support incipient congestion indications via packet marking in instances of packet loss in the network during time-correlated blockages by providing indications in the physical (PHY) layer. A receiver rate calculation is adjusted so that a loss due to blockage is ignored completely and only packets marked using an Explicit Congestion Notification (ECN) packet marking protocol are treated as losses. Receiver rates are modified based on ECN principles to ignore losses. A NORM receiver rate equation may remain substantially unchanged while a sender is enabled to keep sending at a higher data rate, even in instances of blockage in support of higher system throughputs without defining a completely new receiver rate equation. Time-correlated blockages are not treated as losses.

ECN-enabled multicast protocol for wireless communication systems under blockage

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.

Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.

Non-radioactive traceable metal isotope-enriched nanoparticles and method of their use for determining biodistribution

Aspects of the disclosure can provide an ad-hoc network having a clusterhead node and a plurality of nodes associated with the clusterhead, at least one of the plurality of nodes is a remote node and at least one is an intermediate node, the remote node can indirectly communicate with the clusterhead through the intermediate node. The remote node can also transmit network state information at a higher rate, but in lesser amounts, than the intermediate node.

Technique for low-overhead network state dissemination for management of mobile ad-hoc networks

Growing community of inventors

Clifton Park, NY, United States of America

Amit Mohan Kulkarni