The Brigham and Women's Hospital, Inc.

Amit Gandhi

Richard S Blumberg

Robert George Edward Holgate

Susan Dana Jones

Yu-Hwa Huang

Monica Bertagnolli

Charles Yoon

Kristi Baker

Michal Pyzik

Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Humanized and affinity-matured anti-CEACAM1 antibodies

As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.

Methods to manipulate alpha-fetoprotein (AFP)

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Billerica, MA, United States of America

Amit Gandhi