Sakura Finetek U.s.a., Inc.

Biopath Automation, LLC

Amit D Shah

Warren P Williamson, Iv

Richard W Dapson

Erico Von Bueren

Douglas T Yamanishi

Hwai-Jyh Michael Yang

Chen Yu Cheng

Clifford Hom

Cristina R Flores

Chia Hsien Lin

Nick John Booker

Chester John Henderson

Scott Webster

A sectionable tissue sample support structure including a gel compound formed into a self supporting geometric shape for retention and orientation of at least one tissue sample during a histopathology process including processing, embedding and microtome slicing of the tissue sample. A method of orienting, processing, embedding and microtome slicing a tissue sample using a gel compound preformed into a self supporting geometric shape. A combination including the sectionable tissue sample support structure and a package containing the sectionable tissue sample support structure.

Microtome sectionable gel support structure and methods

Apparatuses for measuring sample materials (such as tissue samples) and associated methodologies and instrumentation involve a spectroscopy system or device configured with a sample measuring device (e.g., an attenuated total reflection infrared (ATR-IR) sample measuring device) including a crystal defining a sample receiving surface/interface operatively connected to an IR source and an IR detector. The sample receiving surface/interface facilitates assessing presence (and optionally, amount) of a fixative (e.g., formaldehyde) in sample materials, tissue samples for example. Measurements are taken at one or multiple locations within a sample placement structure/area, which can be provided in the form of a probe or a raised piercing structure containing one or more ATR-IR (or other) sample measuring devices. The probe can include a piercing structure or mechanism at a distal (open) end of the probe configured to create a passage to a selected location (depth) within the sample material in a minimally invasive manner so that the sample is not severely damaged during testing.

Use of IR spectroscopy to evaluate penetration of reagents into biological specimen

A method including placing a biological sample taken from a body into a chamber; adding a composition including an acetal solvent to the chamber; and fixating the biological sample. A method including placing a tissue from a body into a chamber; and contacting the tissue with a composition including an acetal solvent as a fixating process.

Tissue processing reagent

A method including contacting a tissue or cellular sample with a reagent including an evaporation reducing agent(s) having the general formula X&#x2014;R&#x2014;X, wherein R is an alkyl, alkenyl, alkynyl or an aromatic moiety of 1 or more carbon atoms that may be substituted with an oxygen, nitrogen or sulfur and Xand Xare independently selected to be moiety that is susceptible to hydrogen bonding and processing the tissue or cellular sample. A reagent used in the processing of a tissue or cellular sample with the reagent containing an evaporation reducing agent.

Methods to reduce evaporation during elevated temperature

A method including treating a biological sample taken from a body with a composition including an acetal solvent. A method including contacting a fixed biological sample taken from a body with a composition including an acetal solvent as at least one a dehydrating, clearing and infiltration process.

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Redondo Beach, CA, United States of America

Amit D Shah