Carmel—haifa University Economic Corp Ltd.

Amiram Ariel

Aviv Lutaty

Dalit Barkan

Sagie Schif-Zuck

Aroesti-Assi Simaan

Odelya Gilon

The present invention is directed to synthetic anti-inflammatory peptides and use thereof in the treatment and prevention of inflammatory and fibrotic conditions. Specifically, the invention relates in some embodiments to short isolated peptides having the amino acid sequence Phe-Lys-Glu (FKE), Tyr-Lys-Glu (YKE) or comprising a plurality of these sequences that may be flanked by Ala/Gly (A/G) linkers. The invention further relates in some embodiments to methods for inhibiting scar formation and for treating and alleviating IL-10 dependent conditions.

Synthetic anti-inflammatory peptides and use thereof

A conditioned medium of CD11bmacrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11bmacrophages conditioned medium or a culture of CD11bmacrophages and their use in the treatment of cancer or fibrosis are also provided.

CD11 B[low] macrophages and conditioned media thereof for treating cancer and/or fibrosis

Novel lactoferrin fragments that are characteristic of inflammation during resolution and uses thereof. Diagnostic compositions and methods for assessing the presence or absence of resolving inflammation and for monitoring the progression of inflammatory resolution in a subject. Methods for treating a subject having an inflammatory disease, the methods including determining whether the subject has inflammation in resolution by determining the molecular weight of lactoferrin fragments.

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Kiryat Motzkin, Israel

Amiram Ariel