Microbia, Inc.

Whitehead Institute for Biomedical Research

Amir Sherman

Brian Cali

Joshua Trueheart

G Todd Milne

Kevin T Madden

Peter Hecht

John C Royer

Douglas A Holtzman

Steffen Rupp

Mary Maxon

Eric F Summers

Laura Robertson

Radclyffe Roberts

Cora Ann Styles

Hiten Madhani

Hsiu-Jung Lo

Shannon Roberts

Thea Norman

Jeffrey Cruz Silva

Gerald R Fink

Sofie Salama

Todd Milne

Eric Summers

Robert Busby

Doug Holtzman

Jeff Silva

Lixin Zhang

Gerald L Fink

Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.

Modulation of secondary metabolite production by zinc binuclear cluster proteins

The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.

love variant regulator molecules

lovE variant regulator molecules

The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Methods for improving secondary metabolite production in fungi

The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.

Isolated nucleic acid molecule encoding a regulator of fungal gene expression

Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.

Regulation of fungal gene expression

Growing community of inventors

Jerusalem, Israel

Amir Sherman