Ben-gurion University of the Negev Research and Development Authority

Amorphical Ltd.

Enzootic Holdings Ltd.

Other

Ben, Yossi

Amir Sagi

Assaf Shechter

Ohad Rosen

Amir Berman

Oren Meiron

Galit Shaltiel-Gold

Michal Daniely

Shmuel Bentov

Tomer Ventura

Yosef Ben

Yossi Ben

The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.

Functional sex-reversal of decapod crustacean females

The present invention provides an all-female progeny of a decapod crustacean. The invention further provides the newly created: WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean. The crossing of WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean resulted in a 100% homogametic all-WW female progeny.

WW homogametic male decapod crustacean and methods of using the same

Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

Amorphous calcium carbonate for the treatment of calcium malabsorption and metabolic bone disorders

Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

Stable amorphous calcium carbonate comprising synthetic phosphorylated peptides

The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.

Orally-administrable compositions comprising stable amorphous calcium carbonate

Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn() are disclosed. Also disclosed are methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in, useful for producing male monosex populations.

Insulin-like gene of prawns and uses thereof

Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.

Stable amorphous calcium carbonate comprising phosphorylated amino acids

Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.

Composition comprising crustacean gastrolith components and its use

The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn(). The present invention further relates to methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in, useful for producing male monosex populations.

Growing community of inventors

Omer, Israel

Amir Sagi