Technion Research & Development Foundation Ltd

The General Hospital Corporation

Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh

Nrc Soreq

Amir Rozental

Yoav Hazan

Vasilis Ntziachristos

Lucas Riobo

Farouc Amin Jaffer

Aner Lev

Daniel Razansky

Stratis Tzoumas

Ivan Olefir

R Nika Mendelev (Nudelman)

Evgeny Hahamovich

Shai Tsesses

Resmi Ravi Kumar

Assaf Grinberg

Ahiad Levi

R Nika Nudelman

A laser system for acousto-optics imaging is disclosed. The system comprises: a continuous wave laser source; a first beam splitter configured to split a laser emitted by the continuous wave laser source into a lasing beam and a reference beam; a lasing optical fiber diffusing the lasing beam to a subject; a reference optical fiber providing the reference beam; a collecting optical fiber capable of receiving a scattered beam from the subject; a second beam splitter for merging the scattered and reference beams into a merged beam, and at least one photodetector assembly with a bandwidth higher than the ultrasound frequency to detect the merged beam.

Homodyne time-domain acousto-optic imaging for low-gain photodetectors

A system and method of detecting acoustic waves including directing a continuous-wave source laser beam to an optical resonator that is impinged by acoustic the waves. Optionally, the source laser beam can propagate through the optical resonator, thereby generating a propagated laser beam. Using an interferometer, the acoustic waves can be detected by monitoring transients in an optical phase of the propagated laser beam.

Ultrasound detection based on phase shift

A method comprising: generating a pulsed laser beam comprised of non-interfering pulse-pairs having a phase difference, wherein the phase difference changes between each two consecutive cycles of the pulse-pairs; directing the pulsed laser beam at one or more optical resonators, wherein each of the one or more optical resonators is impinged by acoustic waves, to cause the pulsed laser beam to propagate through each of the one or more optical resonators, thereby interfering the pulse-pairs; and calculating shifts in a spectral response of each of the one or more optical resonators based on measuring the interference, wherein the shifts are indicative of a waveform of the acoustic waves.

Phase modulated pulse interferometry for multi-channel ultrasound detection

Apparatus is provided including an acoustic sensor () having an optical waveguide (). The optical waveguide () includes a waveguide core () having a waveguide core refractive index and a waveguide core photo-elastic coefficient, and an over-cladding layer () coupled to the waveguide core () and including an optically transparent polymer having an over-cladding refractive index and an over-cladding photo-elastic coefficient. The waveguide core refractive index is greater than the over-cladding refractive index, and the over-cladding photo-elastic coefficient is greater than the waveguide core photo-elastic coefficient. Other applications are also described.

Polymer-coated high-index waveguide for acoustic sensing

An ultrasound detection device comprising: an ultrasound receiver configured to generate a signal indicative of a pressure of ultrasound that impinges on the receiver; and a coded mask comprising an ultrasound-blocking material perforated by an array of a plurality of apertures, the apertures arranged such that when the coded mask is placed over the receiver between the receiver and a source of ultrasound in a predetermined lateral position, the ultrasound is transmitted from the ultrasound source to the receiver via a known unique pattern of active apertures of the plurality of apertures such that the signal that is generated by the receiver is a multiplexed signal.

Coded aperture ultrasound detector

An apparatus for optical detection of ultrasound includes one or more optical resonators (OR&#x2014;), one or more optical passive-demodulation interferometers (OPDI&#x2014;), and one or more respective electro-optical readout circuits (EORC&#x2014;). The one or more optical resonators (OR) are configured to modulate respective carrier frequencies of optical signals indicative of US waves impinging thereon. The one or more OPDI are implemented in one or more photonic integrated circuits (PIC), wherein each OPDI is configured to demodulate the optical signal output by the respective OR, so as to generate a respective intensity-modulated optical signal. Each OPDI includes an interferometer () having imbalanced arms () that are recombined using an optical hybrid (). The one or more respective EORC are each configured to measure the intensity demodulated optical signal produced by the respective OPDI, and to output a respective electrical signal.

Ultrasound detection by optical passive-demodulation interferometry using photonic integrated circuits (PIC)

A device and an according method for multispectral optoacoustic imaging of an object is provided comprising: an irradiation unit configured to irradiate the object with electromagnetic radiation at two or more different irradiation wavelengths the electromagnetic radiation having a time-varying intensity; a detection unit configured to detect acoustic waves generated in the object upon irradiating the object with the electromagnetic radiation at the different irradiation wavelengths; and a processing unit configured to reconstruct images of the object based on the detected acoustic waves generated in the object at each of the irradiation wavelengths and to determine a spatial distribution of at least one first concentration value, which relates to a concentration of at least one electromagnetic radiation absorber in the object.

Device and method for multispectral optoacoustic imaging

System and method for obtaining information about a target structure. The system includes an optoelectrical element with an optical fiber having a core, a coating surrounding the core, an optical axis, a proximal end, and a distal end. The optoelectrical element also includes an electrical connector embedded within the coating along the optical axis between the proximal end and the distal end. A transducer is disposed at the distal end and electrically connected to the electrical connector. The transducer is operable to detect a first energy, generated in response to light that has been transmitted from the proximal end to the distal end and outcoupled from the distal end toward the target structure, and to convert the received first energy to an electrical signal to be transmitted along the electrical connector.

Hybrid catheter system

An ultrasound detector adapted for ultrasound detection with medical applications includes an optical waveguide, and at least one Bragg grating, created with a predetermined refractive index modulation amplitude in the optical waveguide, wherein the at least one Bragg grating includes a localized defect in periodicity so that a localized-light resonance portion is formed around the defect, and the localized-light resonance portion has spectral properties capable of being modulated in response to an ultrasound oscillation, wherein the optical waveguide is a non-amplifying optical medium, and the refractive index modulation amplitude is selected such that the localized-light resonance portion is concentrated at the defect in periodicity and the ultrasound oscillation can be sensed by the at least one Bragg grating with an acoustic sensitivity most of which being obtained over the localized-light resonance portion.

Growing community of inventors

Haifa, Israel

Amir Rozental