Carefusion 303, Inc.

Immunicom, Inc.

Amir Jafri

Mark Raptis

Ganesh Kathiresan

Alison Burdett

Steven Francis Josephs

Stephen Michael Prince

Okundu Omeni

Mathew Key

Robert Segal

Thomas Emanuel Ichim

David L Schlotterbeck

Matthew Ong

The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological 'blocking factors'. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Increasing responses to checkpoint inhibitors by extracorporeal apheresis

A column for removal of a component from a fluid is disclosed. The column has a compartment with a cross sectional area. The compartment contains beads having a diameter. A ligand selected to bind to the component is coupled to the beads. The cross-sectional area and bead diameter are selected to maintain a flow velocity of the fluid within the compartment below a first threshold, thereby reducing leaching of the ligand into the fluid. Also described herein is an adsorbent comprising a ligand that is attached to a substrate by an amine bond, wherein the ligand is resistant to dissociation from the substrate.

Reduced leaching of a ligand

A vital-signs patch for a patient monitoring system that includes a housing containing a sensor that makes physiological measurements of a patient, a transmitter, a receiver, a memory, and a processor. The processor periodically takes a measurement from the sensor, converts the measurement to a data record, and stores the data record in the memory. Upon receipt of a signal from another device, the processor retrieves at least a portion of the data record, converts the retrieved portion of the data record to a vital-sign signal, and causes the transmitter to transmit the vital-sign signal to the other device.

System and method for storing and forwarding data from a vital-signs monitor

A vital-signs patch for a patient monitoring system is disclosed. The patch consists of a housing that is configured to be worn on the skin of a patient. The housing contains a radio, one or more sensor interfaces, a processor, and a battery. The processor can selectably turn portions of the processor off and on and selectably turn power off and on to at least a portion of the sensor interfaces and radio. The processor includes a timer that, each time the timer times out, will turn all the parts of the processor on and start a new timing period. When the processor receives a signal, the processor will turn off power to at least a portion of the processor and at least a portion of the sensor interfaces.

System and method for saving battery power in a patient monitoring system

The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNF&#x3b1;. The system and method are useful for the treatment of different cancer types, stages and severity.

System and method for removal of immune inhibitors from biological fluids

A vital-signs patch in a patient monitoring system is disclosed. The patch includes a housing configured to be attached to the skin of a patient, the housing containing a radio that can selectably transmit and receive on more than one frequency and a processor. The processor configures the radio to transmit and receive on a determined frequency based at least in part on the level of noise detected on the frequencies.

Growing community of inventors

San Diego, CA, United States of America

Amir Jafri