Koninklijke Philips Corporation N.v.

Amir Hussein Rmaile

Marinus Karel Johannes De Jager

John Taylor

Philip Preshaw

Steven Charles Deane

Gerben Kooijman

Michael Alex Van Hartskamp

Supriyo Chatterjea

Rim Helaoui

Mark Thomas Johnson

Ronaldus Maria Aarts

Vincent Jeanne

Johannes Hendrikus Maria Spruit

Okke Ouweltjes

Caifeng Shan

Neil Francis Joye

Lutz Christian Gerhardt

Bart Jacob Bakker

Edgar Martinus Van Gool

Radu Serban Jasinschi

Yekaterina Borisenko

Dionisio Massingo Nunes

Aleksandro Grabulov

Maaike Cornelia Johanna Wilhelmina Van Hulten

Pieter Horstman

Jayprakash Patel

Priscilla BRANDÃO Silva

Melissa Mackay Grant

John J Taylor

Nigel David Young

Achim Rudolf Hilgers

Carl Glasse

Iain Leslie Campbell Chapple

Disclosed is a system, a kit, a use and an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The system and method are based on the insight to apply a clustering technique to a reference set of patient data, and then further discriminating the sets of bio markers to be applied. The clusters are determined on the basis of the biomarkers Hepatocyte Growth Factor (HGF), Matrix metalloproteinase 8 (MMP8), and Matrix metalloproteinase 9 (MMP9). The actual classification of the patient is done on the basis of the measurement of the concentrations of either of two sets of biomarkers. For one cluster these are Interleukin-1β (IL1β), Interleukin-6 (IL6), and Collagen Telopeptide. For the other cluster, these are HGF and metallopeptidase inhibitor 1 (TIMP1).

Classification of periodontitis patients

Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Interleukin-1β (IL-1β), Matrix metalloproteinase-9 (MMP-9) and at least one of the proteins: Interleukin-6 (IL-6), and Matrix metalloproteinase-3 (MMP-3). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.

Diagnostics of mild or advanced periodontitis based on salivary IL-1BETA and MMP-9

Disclosed is an in vitro method for assessing whether a human subject has periodontitis. The method comprises detecting, in a sample of saliva from said subject, the concentrations of the proteins Hepatocyte Growth Factor (HGF) and Matrix Metalloproteinase 8 (MMP-8). Based on the concentrations determined, and adding age, and possibly other demographic markers such as sex and/or BMI, a testing value reflecting the joint concentrations is determined for said proteins, in combination with one or more demographic markers. The testing value is compared with a threshold value. The threshold reflects in the same manner the joint concentrations and the age, and possibly other demographic markers, as associated with periodontitis and may be seen as an upper limit of testing values as seen in a population of subjects without periodontitis. Thereby a testing value at or above the threshold value is indicative for periodontitis in said subject.

Diagnostics of periodontitis based on salivary HGF and MMP-8

A system for detecting halitosis is disclosed that comprises a gas sensor () for generating a sensor signal signalling the detection of compounds indicative of halitosis exhaled through an oral cavity; an image sensor () for capturing an image () of a dental condition and/or tongue condition in said oral cavity; and a processor () communicatively coupled to the gas sensor and the image sensor and adapted to process the sensor signal and the image in order to determine if in case of the sensor signal signalling the presence of a compound indicative of halitosis, said halitosis originates from said oral cavity by determining the dental condition and/or tongue condition in said image. A method for detecting halitosis and a computer program product implementing the method are also disclosed.

System and method for detecting halitosis

A method () for modifying a user's oral care program. The method includes the steps of: (i) providing () a network () comprising a first personal care device () in communication with a second personal care device (); (ii) cleaning () at least a portion of the oral cavity using the first personal care device; (iii) obtaining (), while cleaning with the first personal care device, sensor data for the at least a portion of the oral cavity; (iv) communicating () the obtained sensor data to the second personal care device; and (v) modifying (), based on the communicated sensor data, a function of the second personal care device.

Network for collaborating personal care devices

An oral cleaning system provides motivating feedback to a user before brushing and includes: a power toothbrush (); one or more sensors () on or within the toothbrush; a processor () within the toothbrush configured to process sensor information obtained from the one or more sensors during a first brushing session of a user; and a feedback system () on or within the toothbrush responsive to the processor and configured to communicate brushing information to the user at a time subsequent to the first brushing session but before a second brushing session of the user.

Systems and methods for providing motivation feedback to a user before brushing

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Eindhoven, Netherlands

Amir Hussein Rmaile