National Institutes of Health, a Component of the US Dept. of Health & Human Services

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Amir H Gandjbakhche

Victor Chernomordik

Paul Reed Smith

Edward Wellner

David Hattery

James G Smirniotopoulos

Eric Wassermann

Franck Amyot

Jim Mulshine

Paul D Smith

Albert Claude Boccara

Ilko Kolev Ilev

Ronald W Waynant

Alexander Sviridov

Moinuddin Hassan

Jason D Riley

Zachary Ulissi

Israel Gannot

Eric Wasserman

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light. The near infrared light is emitted at two distances from a brain of the patient, so the emitted light penetrates to two different depths. Such a method also includes applying a ratiometric analysis to the reflected light to distinguish a border between normal tissue and tissue exhibiting blood accumulation.

Method for detecting hematoma, portable detection and discrimination device and related systems and apparatuses

A polarization-based colposcopy apparatus includes a polarization exchanging beam splitter pair oriented so that s- and p-polarizations are exchanged. An optical flux from a specimen is directed through the pair, and orthogonal components thereof are alternately or selectively coupled to an array detector. The detected images are processed based on image correlations to reveal specimen structures.

Polarimetric accessory for colposcope

An ultrahigh-resolution fiber-optic confocal microscope has an illumination system; three single-mode optical fibers, each optically coupled to a fiber coupler; a sample support stage arranged to receive illumination radiation from an end of one of the single-mode optical fibers; a detector arranged to receive output radiation from one of the single-mode optical fibers; and a lock-in amplifier electrically connected to the detector and the illumination system. The illumination system is adapted to provide illumination radiation that has a time-varying strength that is correlated with the detector by the lock-in amplifier.

Ultrahigh-resolution fiber-optic confocal microscope and method

The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.

Methods of detecting inflammation of an epithelium layer in the oral region with a probe using diffuse-reflectance spectroscopy

Probe using diffuse-reflectance spectroscopy

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Potomac, MD, United States of America

Amir H Gandjbakhche