The National Institute for Biotechnology in the Negev Ltd.

The National Institute for Biotechnology I

Amir Aharoni

Marianna Zaretzky

Itay Levin

Death-domain receptor 3 (DR3) variants having increased binding affinity to TL1A, and composition comprising same, are provided. Further, methods of use of said peptides or composition, including, but not limited to treatment of autoimmune and/or inflammatory disease are provided.

Variants of DR3 and use thereof

A protein comprising an amino acid sequence having at least 97% homology to SEQ ID NO: 1. The amino acid sequence comprises valine at position 60, glycine at position 123 and lysine at position 109 and the protein binds hIL17A.

IL-17R-ECD mutants and methods of using same

Provided are engineered soluble hIL-17RA receptors with high affinity to hIL-17 that inhibit downstream IL17A induced signaling events in cells. Also provided are methods of inhibiting hIL-17A induced secretion of CXCL1 and/or IL-6 in cells, as well as methods of treating inflammation and/or inflammatory disorders in a subject.

Growing community of inventors

Beit Kama, Israel

Amir Aharoni