University of Washington

University System of Maryland

The University of British Columbia

Tokai Pharmaceuticals, Inc.

Amina Zoubeidi

Martin E Gleave

Vincent C O Njar

Douglas B Jacoby

Karen Ferrante

Eva Corey

Masafumi Kumano

François Lamoureux

Sepideh Vahid

Daksh Thaper

Jennifer L Bishop

Ravi Shashi Nayana Munuganti

Described herein are methods and compositions for the treatment of prostate cancer in a subject in need thereof. The prostate cancer may be a castration resistant and an androgen receptor antagonist-resistant prostate cancer. The methods may comprise administering to the subject a CYP17-lyase inhibitor of Formula II.

Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Combination therapy for cancer makes use of HSP27 inhibitors and EGFR tyrosine kinase inhibitors or etiolates.

Combination therapy for cancer using HSP27 inhibitor and EGFR tyrosine kinase inhibitors or anti-folates

The present invention provides a method for treating a mammalian subject affected by prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) a Heat Shock Protein 90 (Hsp90) inhibitor each in an amount that when in combination with the other is effective to treat the mammalian subject. The present invention also provides pharmaceutical compositions comprising an amount of an oligonucleotide which reduces clusterin expression, and a Hsp90 inhibitor for use in treating a mammalian subject affected by prostate cancer. Also provided are oligonucleotides which reduce clusterin expression for use in combination with a Hsp90 inhibitor in treating a mammalian subject affected by prostate cancer, and a composition for treating a mammalian subject affected by prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) a Hsp90 inhibitor each in an amount that when in combination with the other is effective to treat the mammalian subject.

Combination of anti-clusterin oligonucleotide with Hsp90 inhibitor for the treatment of prostate cancer

Growing community of inventors

Vancouver, Canada

Amina Zoubeidi