Oregon Health & Science University

Novartis Ag

Technische Universitat Munchen

Centre Hospitalier Régional Universitaire De Lille

Medvet Science Pty Ltd

Université Victor Segalen—bordeaux 2

University of Heidelberg

Amie Corbin

Brian Jay Druker

Martin Mueller

Andreas Hochhaus

Sebastian Kreil

Christophe Barthe

Christian Peschel

Thibaut Leguay

Claude Preudhomme

Zbigniew Rudzki

Susan Branford

Catherine Roche Lestienne

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

Detection of gleevec resistance

Detection of gleevec resistant mutations

Growing community of inventors

Portland, OR, United States of America

Amie Corbin