The Wistar Institute

University of Pennsylvania

Inovio Pharmaceuticals, Inc.

Ami Patel

David B Weiner

Jian Yan

Sarah Elliott

Kar Muthumani

Kate Broderick

Makan Khoshnejad

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.

consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensusglycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response againstare disclosed. Method of preventingand methods of treating individuals infected withare disclosed. Consensusproteins are disclosed.

Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.

DNA-encoded monoclonal antibodies targeting the Ebolavirus glycoprotein

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.

Nucleic acid monoclonal antibodies targeting PCSK9 and methods of use

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

DNA monoclonal antibodies targeting influenza virus

Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.

Vaccines against coronavirus and methods of use

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensusfilovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response againstare disclosed. Method of preventing infection byand methods of treating individuals infected withare disclosed. Consensusfilovirus glycoprotein immunogens are disclosed.

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Philadelphia, PA, United States of America

Ami Patel