Yeda Research and Develpment & Co. Ltd

Ami Navon

Varda Rotter

Moshe Oren

Benjamin Geiger

Zvi Kam

Irina Lavelin

A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.

Growing community of inventors

Rehovot, Israel

Ami Navon