Johns Hopkins University

Ami A Shah

Antony Rosen

Livia Angela Casciola-Rosen

Bert Vogelstein

Kenneth W Kinzler

Nickolas Papadopoulos

Marikki Laiho

Erika Darrah

Takeru Igusa

Marikki K Laiho

Christine Joseph

This document relates to materials and methods for assessing and/or treating subjects (e.g., subjects having autoimmune diseases). For example, materials and methods for determining if a subject (e.g., a human having an autoimmune disease) has one or more antibodies that can be used to identify the subject as having a lower risk of cancer or as having a higher risk of cancer are provided. Materials and methods for treating a subject (e.g., a human) identified as having a higher cancer risk for cancer are also provided.

Materials and methods for assessing cancer risk and treating cancer

Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses. Acquired immunity to autoimmune antigens can help control naturally occurring cancers.

Autoimmune antigens and cancer

Growing community of inventors

Ellicott City, MD, United States of America

Ami A Shah