University of California

Pfizer Corporation

Amha Atakilit

Dean Sheppard

Neil Cowan Henderson

Isaac J Rondon

Joseph Dal Porto

Dharmaraj Samuel

Matthew Ross Drever

Charles Ray Holst

Kyle Steven Niessen

Dominique Meyer

George Wen Su

Rosemary J Akhurst

Kamran Atabai

Sayyed M Amin Khalifeh-Soltani

Rosemary J Akurst

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to αvβ8 integrin. The invention includes uses, and associated methods of using the antibodies.

Method of treating cancer using anti-AV8 antibodies

Methods and compositions comprising integrin &#x3b2;8 antibodies are provided.

Methods and compositions for treating and preventing disease associated with alpha-v beta-8 integrin

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to &#x3b1;v&#x3b2;8 integrin. The invention includes uses, and associated methods of using the antibodies.

Anti-AVB8 antibodies and compositions and uses thereof

The present invention provides compositions and methods for treating and preventing disease associated with &#x3b1;v&#x3b2;5 integrin by blocking binding to &#x3b1;v&#x3b2;5 integrin. In particular, antibodies specific for &#x3b1;v&#x3b2;5 integrin are useful for preventing, treating, and reversing sepsis.

Methods and compositions for treating and preventing disease associated with &#x3b1;v&#x3b2;5 integrin

Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. The method comprises administering an antagonist of integrin &#x3b1;&#x3b2;or &#x3b1;&#x3b2;to an animal in an amount sufficient to reduce fatty acid uptake in the animal, thereby reducing fatty acid uptake in the animal. In some embodiments, the antagonist is an antibody. Also provided is a method of increasing fatty acid uptake and/or gastric motility in an animal.

Milk fat globule epidermal growth factor 8 regulates fatty acid uptake

Antibodies (e.g., isolated antibodies) that specifically bind to human integrin &#x3b2;8 and inhibit adhesion of latency associated peptide (LAP) to &#x3b1;v&#x3b2;8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin &#x3b2;8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to &#x3b1;&#x3b2;8 with an IC50 below 5 nM.

Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin

The present invention provides compositions and methods for treating and preventing disease associated with &#x3b1;v&#x3b2;5 integrin by blocking binding to &#x3b1;v&#x3b2;5 integrin.

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Oakland, CA, United States of America

Amha Atakilit