Affibody Ab

Ge Health Bio-sciences Ab

Ge Healthcare Bio-sciences Ab

Amelie Eriksson Karlström

Sophia Hober

Fredrik Frejd

Caroline Ekblad

Joel Lindgren

Anna Konrad

The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to proteolytic cleavage and therapeutic use thereof. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence 

Engineered albumin binding polypeptide

The present invention relates to site-specific labeling of antibodies or fragments thereof with one or more reporter group(s) in a way that does not affect antigen binding. The method for labeling antibodies and/or fragments thereof, comprises the following steps a) providing an IgG binding protein, which comprises &#x3b1;-helix structures, with a photoactivatable group and at least one label; b) forming a mixture of said IgG binding protein and the antibodies and/or fragments to be labeled; and c) UV illuminating said mixture for site-specific labeling of said antibodies and/or fragments thereof. The IgG binding protein is preferably the Z domain of Protein A.

Method for labeling of compounds

Growing community of inventors

Bromma, Sweden

Amelie Eriksson Karlström