The General Hospital Corporation

The Broad Institute, Inc.

Instituto Carlos Slim De La Salud, A.c.

Amedeo Vetere

Sean M Burns

Bridget K Wagner

David Altshuler

Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods.

Compounds and methods for regulating insulin secretion

Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods. The compounds may have the structure of formula I(a): wherein the substituents are as described in the description;or a pharmaceutically acceptable form thereof.

The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.

Growing community of inventors

Cambridge, MA, United States of America

Amedeo Vetere