University of Pittsburgh

Universitá Degli Studi Di Cagliari

International Society for Drug Development S.r.l.

Purytra Farmaceutici S.r.l.

Amedeo Columbano

Simona Rapposelli

Guido Puricelli

Grazia Chiellini

Andrea Perra

Satdarshan Pal Singh Monga

Sheraz Gul

Massimiliano Runfola

The invention concerns a compound of Formula (I) or a salt thereof, wherein Ris H, (C-C)alkyl or CF; Ris H, (C-C)alkyl or CF; A is CHCOOH, XCHCOOCHCH, XCHCOOH, XCHCHNH, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where Ris H, —CH, —CHCHor CHCO—, Ris H or —CH, R5 is H or —CH, and Ris H or —CH. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).

Thyromimetics with a biphenylmethane scaffold and their use

Methods are disclosed for the use of GC-1 (sobetirome), a prodrug thereof, or a pharmaceutically acceptable salt or prodrug thereof to increase liver regeneration and healing in liver transplant donors and recipients.

Use of GC-1 in transplant related population

Growing community of inventors

Selargius, Italy

Amedeo Columbano