Acelot, Inc.

University of California

Oracle International Corporation

Ambuj Kumar Singh

Christian Alexander Lang

Sayan Ranu

Huahai He

Siva Ravada

Jayanta Banerjee

Ravi Kothuri

Jayant Sharma

The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Small molecule drugs and related methods for treatment of diseases related to TDP-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation

Described herein, inter alia, are certain substituted piperazines, for example, having the Formula 182, and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Substituted piperazines as disrupters of AB42 oligomer formation

The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A&#x3b2;42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A&#x3b2;42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition. One such compound is a compound of formula 120:

Substituted amines as disrupters of ABETA42 oligomer formation

The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A&#x3b2;42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A&#x3b2;42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Small molecule drugs and related methods for treatment of diseases related to A&#x3b2;42 oligomer formation

A technique for mining pharmacophore patterns including computer-implemented methods for generating a database of pharmacophores and computer-implemented methods for classifying a query molecule with the database of pharmacophores. Generation of the pharmacophore database includes methods of defining a Joint Pharmacophore Space (JPS) using the three-dimensional geometry of pharmacophoric features of all active molecules against multiple targets.

Defining and mining a joint pharmacophoric space through geometric features

A method for analyzing, querying, and mining graph databases using subgraph and similarity querying. An index structure, known as a closure tree, is defined for topological summarization of a set of graphs. In addition, a significance model is created in which the graphs are transformed into histograms of primitive components. Finally, connected substructures or clusters, comprising paths or trees, are detected in networks found in the graph databases using a random walk technique and a repeated random walk technique.

Graph querying, graph motif mining and the discovery of clusters

Methods are provided for buffering nodes of a hierarchical index (e.g., R-tree, bang file, hB-tree) during operations on multi-dimensional data represented by the index. The methods are particularly suited for query operations, and a different method may be more suitable for one pattern of queries than another. Where queries are distributed in a relatively uniform manner across the domain or dataspace of an index, a node-area buffering method is provided. In this method nodes are cached or buffered in order of their respective areas (e.g., their minimum bounding areas), and a node having a smaller area will be replaced in cache before a node having a larger area. When, however, queries are not uniformly distributed, then a least frequently accessed buffering technique may be applied. According to this method statistics are maintained concerning the frequency with which individual index nodes are accessed. Those accessed less frequently are replaced in cache before those accessed more frequently. Yet another, generic, buffering strategy is provided that is suitable for all patterns of query distribution. In accordance with this method, whenever a node must be removed from cache in order to make room for a newly accessed node, cached nodes are compared to each other to determine which provides the least caching benefit and may therefore be ejected. A comparison may involve three factors&mdash;the difference in the nodes' areas, the difference in the frequency with which they have been accessed and the difference between their latest access times. These factors may be weighted to give them more or less effect in relation to each other.

Growing community of inventors

Santa Barbara, CA, United States of America

Ambuj Kumar Singh